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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Trends Neurosci. 2015 Nov 24;38(12):763–775. doi: 10.1016/j.tins.2015.10.004

Figure 3. Tentative Assignment of Roles to Different Cell Types.

Figure 3

Operations during the first and second halves of the theta cycle, respectively. Numbering corresponds to sequences of operations during a theta cycle. Place cells can be driven by the lateral entorhinal cortex (LEC) or the medial entorhinal cortex (MEC). Path integrator is assumed to provide input to layer II grid cells. (A) During the first half of the theta cycle, information from LEC and MEC is combined in CA3 to determine the improved estimate of current position, which is then imposed onto grid cells. (B) In the second half of the theta cycle, integration of an artificial velocity vector (AVV) by the grid cell network produces mind-travel, which in turn drives mind-travel in the hippocampus. Red Xs show pathways that are inactivated, perhaps by a signal from interneurons that fire at the appropriate theta phase (phase-locked interneuron firing has been observed [90]).