Table 4.
Associations Between Mid-life Risk Factors and Cogstate Composite Scores*
| DET + IDN (n=1,672) (psychomotor speed, attention) |
OCL + ONB (n=1,597) (learning, working memory) |
Overall Cognition (n=1,559) |
||||
|---|---|---|---|---|---|---|
| β | p | Β | p | β | P | |
| Age (years) | −0.03 (−0.04, −0.02) | <0.001 | −0.04 (−0.04, −0.03) |
<0.001 | −0.03 (−0.04, −0.03) |
<0.001 |
| Body mass index | ||||||
| <22 kg/m2 | 0.03 (−0.11, 0.18) | 0.65 | −0.07 (−0.19, 0.05) | 0.28 | −0.03 (−0.14, 0.08) | 0.62 |
| 22–24.9 kg/m2 (ref.) | - | - | - | - | - | - |
| 25–29.9 kg/m2 | 0.00 (−0.09, 0.10) | 0.93 | −0.02 (−0.10, 0.06) | 0.63 | −0.01 (−0.09, 0.06) | 0.69 |
| 30+ kg/m2 | 0.19 (−0.01, 0.40) | 0.06 | 0.12 (−0.05, 0.29) | 0.17 | 0.17 (0.01, 0.32) | 0.04 |
| Physical activity, MET- hr/wk |
||||||
| First quartile (ref.) | - | - | - | - | - | - |
| Second quartile | −0.04 (−0.15, 0.08) | 0.54 | 0.01 (−0.09, 0.11) | 0.85 | −0.04 (−0.14, 0.05) | 0.34 |
| Third quartile | 0.06 (−0.06, 0.18) | 0.31 | 0.13 (0.03, 0.24) | 0.01 | 0.08 (−0.01, 0.18) | 0.08 |
| Fourth quartile | 0.10 (−0.02, 0.22) | 0.09 | 0.03 (−0.07, 0.13) | 0.58 | 0.06 (−0.03, 0.15) | 0.20 |
| p-trend | 0.02 | 0.56 | 0.049 | |||
| Alcohol, servings/day | ||||||
| None (ref.) | - | - | - | - | - | - |
| 1–2 | −0.02 (−0.11, 0.07) | 0.67 | 0.00 (−0.08, 0.08) | 0.96 | −0.02 (−0.09, 0.05) | 0.63 |
| >2 | −0.07 (−0.21, 0.07) | 0.32 | 0.02 (−0.10, 0.13) | 0.76 | −0.04 (−0.15, 0.06) | 0.45 |
| Nut Intake, servings | ||||||
| <1/month (ref.) | - | - | - | - | - | - |
| 1–3/month | 0.01 (−0.12, 0.14) | 0.91 | −0.01 (−0.12, 0.10) | 0.85 | 0.02 (−0.08, 0.12) | 0.73 |
| 1–2/week | −0.02 (−0.14, 0.09) | 0.67 | 0.05 (−0.05, 0.14) | 0.36 | 0.02 (−0.06, 0.11) | 0.60 |
| >2/week | 0.05 (−0.09, 0.18) | 0.51 | 0.08 (−0.03, 0.20) | 0.16 | 0.08 (−0.02, 0.19) | 0.13 |
| p-trend | 0.40 | 0.12 | 0.11 | |||
| Fish Intake, servings | ||||||
| <1/month (ref.) | - | - | - | - | - | - |
| 1–3/month | 0.29 (0.08, 0.49) | 0.006 | 0.01 (−0.17, 0.19) | 0.91 | 0.13 (−0.03, 0.29) | 0.10 |
| 1–2/week | 0.31 (0.13, 0.49) | <0.001 | 0.03 (−0.12, 0.19) | 0.67 | 0.15 (0.01, 0.29) | 0.03 |
| >2/week | 0.28 (0.09, 0.46) | 0.004 | 0.04 (−0.12, 0.20) | 0.64 | 0.15 (0.00, 0.29) | 0.04 |
| p-trend | 0.42 | 0.65 | 0.38 | |||
| Hypertension | −0.05 (−0.18, 0.08) | 0.47 | 0.03 (−0.08, 0.14) | 0.57 | 0.01 (−0.10, 0.11) | 0.91 |
| Myocardial infarction | −0.09 (−0.67, 0.49) | 0.75 | 0.14 (−0.31, 0.60) | 0.54 | −0.01 (−0.44, 0.42) | 0.97 |
*
Higher scores indicate better performance. All variables were placed into the same model.