Figure 1.
miR-34a is upregulated in AH livers and in the livers of DDC re-fed mice. A Transcription expression of upstream regulators of AH livers by RNA-Seq analyses was shown. B, Increased expression of miR-34a in the livers of alcoholic hepatitis patients was measured by RNA-Seq and qRT-PCR, respectively. C, Induction of miR-34a in the livers of DDC re-fed mice. miRNA expression was quantified by TaqMan miRNA assays (Applied Biosystems). The data were normalized to U6 snRNA (endogenous control) and shown as fold change over the normal livers. Data represent mean values ±S.E.M. *p<0.05, **p<0.01, and ***p<0.001