Skip to main content
. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: J Autoimmun. 2015 Sep 3;65:56–63. doi: 10.1016/j.jaut.2015.08.006

Fig. 5.

Fig. 5

Role of individual cathepsins on Th17 differentiation. A and B) Effect of select cathepsin inhibitors. CD4 cells were differentiated under Th17 polarizing conditions with the indicated inhibitors. A) CLIK195 (20 μM), IW-CHO (20 μM) and CA074-OMe (5 μM). B) Dose-dependent effects of IW-CHO and CLIK195. C) Naïve CD4 T cells from WT and ctsh−/− mice differentiated under Th17 conditions. Data are from (A and B) 3 experiments and (C) 5 mice/group and are shown as (A) representative profiles, (B) means ± SEM and (C) representative profiles (left) and means ± SEM (right). *P < 0.05, **P <0.01.