Table 2.
Clinical and demographic characteristics of the study population.
| No intra-amniotic inflammation (n=85) |
Sterile intra-amniotic inflammation (n=35) |
p value (no intra-amniotic inflammation vs. sterile intra-amniotic inflammation) |
Microbial- associated intra- amniotic inflammation (n=15) |
p value (no intra-amniotic inflammation vs. microbial associated intra-amniotic inflammation) |
p value (sterile intra-amniotic inflammation vs. microbial associated intra-amniotic inflammation) |
|
|---|---|---|---|---|---|---|
| Maternal age (years) | 23 (20 – 26) | 23 (20 – 26.2) | 0.8 | 24 (20 – 30) | 0.7 | 0.4 |
| BMI (kg/m2) | 23 (20 – 29) | 23 (20 – 32) | 0.6 | 27 (23 – 37) | 0.04 | 0.2 |
| Frequency of sonographic short cervix | 16.5% (14/85) | 11.8% (10/85) | 0.04 | 20% (3/15) | 0.35 | 0.9 |
| Antenatal corticosteroid administration | 45% (37/82)* | 20% (7/35) | 0.012 | 46.7% (7/15) | 1 | 0.06 |
| Gestational age at amniocentesis (weeks) |
32 (29 – 33) | 25 (23 – 32) | <0.001 | 26 (23 – 32) | 0.006 | 0.83 |
| AF white blood cells (cells/mm3) | 1 (0 – 5) | 3 (1 – 17) | 0.007 | 295 (2 – 960) | <0.001 | 0.018 |
| AF glucose (mg/dL) | 29 (24 – 34) | 22 (18 – 28) | 0.001 | 11 (10 – 20) | <0.001 | 0.002 |
| AF interleukin-6 (ng/mL) | 0.8 (0.5 – 1.1) | 12 (5 – 21) | <0.001 | 96 (17 – 266) | <0.001 | <0.001 |
| Gestational age at delivery (weeks) | 36 (34 – 38) | 27 (24 – 32) | <0.001 | 26 (24 – 33) | <0.001 | 0.64 |
| Composite neonatal morbidity | 11% (9) | 68% (24) | <0.001 | 67% (10) | <0.001 | 1.0 |
| Acute placental inflammation¥ | 22.5% (18/80) | 61% (19/31) | <0.001 | 79% (11/14) | <0.001 | 0.14 |
| Acute histologic chorioamnionitis | 21% (17/80) | 58% (18/31) | <0.001 | 79% (11/14) | <0.001 | 0.04 |
| Funisitis | 13% (10/80) | 29% (9/31) | 0.06 | 57% (8/14) | <0.001 | 0.26 |
Data presented as median (interquartile) and percentage and (n); AF: amniotic fluid; BMI: body mass index. Acute placental inflammation: acute histologic chorioamnionitis and/or acute funisitis, Composite neonatal morbidity: the presence of respiratory distress syndrome, bronchopulmonary dysplasia, grade III or IV intraventricular hemorrhage, periventricular leukomalacia, proven neonatal sepsis, and necrotizing enterocolitis or perinatal mortality.
¥
Placenta acute inflammation was calculated over a total of 125 specimens.
*
Data were not available in 3 patients