Table 3.
Amniotic fluid inflammatory-related protein concentrations in subgroups of patients with preterm labor and intact membranes
| Sterile intra-amniotic inflammation vs. No intra-amniotic inflammation |
Microbial associated intra-amniotic inflammation vs. No intra-amniotic inflammation |
Microbial associated intra-amniotic inflammation vs. Sterile intra-amniotic inflammation |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Proteins | Fold Change | p-value | q-value | Fold Change | p-value | q-value | Fold Change | p-value | q-value |
| IL-8 | 11.4 | 0.000 | 0.000 | 106.0 | 0.000 | 0.000 | 9.3 | 0.000 | 0.000 |
| IL-6 | 10.6 | 0.000 | 0.000 | 115.4 | 0.000 | 0.000 | 10.9 | 0.000 | 0.000 |
| MIP1-β | 5.3 | 0.000 | 0.000 | 64.8 | 0.000 | 0.000 | 12.3 | 0.000 | 0.000 |
| MCP-1 | 3.8 | 0.000 | 0.000 | 18.5 | 0.000 | 0.000 | 4.8 | 0.000 | 0.000 |
| MIP1-α | 3.4 | 0.000 | 0.000 | 39.8 | 0.000 | 0.000 | 11.6 | 0.000 | 0.000 |
| Calgranulin C | 3.1 | 0.000 | 0.000 | 12.0 | 0.000 | 0.000 | 3.9 | 0.000 | 0.000 |
| IL-1β | 2.8 | 0.002 | 0.006 | 30.6 | 0.000 | 0.000 | 11.1 | 0.000 | 0.000 |
| RANTES | 2.5 | 0.001 | 0.002 | 6.6 | 0.000 | 0.000 | 2.6 | 0.010 | 0.010 |
| MIP3-α | 2.5 | 0.000 | 0.000 | 10.9 | 0.000 | 0.000 | 4.4 | 0.000 | 0.000 |
| Gro-α/CXCL1 | 2.4 | 0.000 | 0.000 | 8.7 | 0.000 | 0.000 | 3.6 | 0.000 | 0.000 |
| Calgranulin A | 2.1 | 0.003 | 0.007 | 15.2 | 0.000 | 0.000 | 7.2 | 0.000 | 0.000 |
| IL-10 | 2.1 | 0.001 | 0.004 | 12.9 | 0.000 | 0.000 | 6.3 | 0.000 | 0.000 |
| MIG | 1.8 | 0.003 | 0.007 | 4.6 | 0.000 | 0.000 | 2.5 | 0.001 | 0.001 |
| ITAC/CXCL11 | 1.8 | 0.000 | 0.001 | 4.6 | 0.000 | 0.000 | 2.6 | 0.000 | 0.000 |
| IP-10/CXCL-10 | 1.8 | 0.020 | 0.028 | 4.0 | 0.000 | 0.000 | 2.3 | 0.017 | 0.017 |
| IL-1α | 1.7 | 0.047 | 0.060 | 11.0 | 0.000 | 0.000 | 6.6 | 0.000 | 0.000 |
| IL-12 | 1.7 | 0.010 | 0.019 | 6.6 | 0.000 | 0.000 | 3.9 | 0.000 | 0.000 |
| TNF-α | 1.7 | 0.008 | 0.016 | 7.7 | 0.000 | 0.000 | 4.6 | 0.000 | 0.000 |
| IL-16 | 1.6 | 0.003 | 0.007 | 5.3 | 0.000 | 0.000 | 3.2 | 0.000 | 0.000 |
| IL-2 | 1.6 | 0.037 | 0.051 | 5.3 | 0.000 | 0.000 | 3.3 | 0.000 | 0.000 |
| IL-13 | 1.6 | 0.013 | 0.023 | 4.6 | 0.000 | 0.000 | 2.9 | 0.000 | 0.000 |
| IL-15 | 1.6 | 0.014 | 0.023 | 4.4 | 0.000 | 0.000 | 2.8 | 0.000 | 0.000 |
| GMCSF | 1.5 | 0.058 | 0.068 | 5.3 | 0.000 | 0.000 | 3.4 | 0.000 | 0.000 |
| IFN-γ | 1.5 | 0.013 | 0.023 | 6.1 | 0.000 | 0.000 | 4.0 | 0.000 | 0.000 |
| HMGB-1 | 1.5 | 0.072 | 0.082 | 7.4 | 0.000 | 0.000 | 4.9 | 0.000 | 0.000 |
| TGF-β | 1.5 | 0.016 | 0.024 | 4.2 | 0.000 | 0.000 | 2.8 | 0.000 | 0.000 |
| MCSF | 1.5 | 0.050 | 0.061 | 5.6 | 0.000 | 0.000 | 3.8 | 0.000 | 0.000 |
| IL-4 | 1.5 | 0.155 | 0.165 | 5.1 | 0.000 | 0.000 | 3.5 | 0.001 | 0.001 |
| Eotaxin | 1.4 | 0.014 | 0.023 | 4.3 | 0.000 | 0.000 | 3.0 | 0.000 | 0.000 |
| Lactoferrin | 1.4 | 0.039 | 0.051 | 3.5 | 0.000 | 0.000 | 2.4 | 0.000 | 0.000 |
| IL-7 | 1.4 | 0.076 | 0.084 | 5.0 | 0.000 | 0.000 | 3.6 | 0.000 | 0.000 |
| IL-33 | 1.1 | 0.629 | 0.649 | 3.5 | 0.001 | 0.001 | 3.1 | 0.003 | 0.003 |
| IL-18 | 1.1 | 0.698 | 0.698 | 2.5 | 0.000 | 0.000 | 2.4 | 0.000 | 0.000 |
IFN-γ: interferon gamma; IL: interleukin; IP-10: interferon gamma-induced protein 10; GM-CSF: granulocyte macrophage colony-stimulating factor; MCSF: macrophage colony-stimulating factor, Gro-α/CXCL1: C-X-C motif ligand 1; HMGB-1: high-mobility group protein 1; ITAC/ CXCL11: Interferon-inducible T-cell alpha chemoattractant/C-X-C motif ligand 11; MDC: macrophage-derived chemokine; MIP: macrophage inflammatory protein; MIG: Monokine induced by gamma interferon; MCP: monocyte chemoattractant protein-1; RANTES: regulated on activation, normal T cell expressed and secreted; TNF: tumor necrosis factor, TARC: thymus and activation-regulated chemokine