TABLE 1.

Comparing CNS dissemination of three distinct neurotropic viruses

	Reovirus T3D	Poliovirus	YFV-17D
Viral titer in brain of adult IFNAR+/+ mice	Undetectable	Very low	Moderate
Probable dissemination route to brain	Peripheral neurons	Peripheral neurons	Blood
Primary barrier	Age	Age	Interferon
Secondary barrier	Interferon	Inefficient retrograde axonal transport	Age
Tertiary barrier	---	Interferon	---
Effect of muscle damage	~ No effect	↓ Dissemination	↓ Dissemination
Effect of IFNAR−/−	↑ Dissemination	↑ Dissemination	↑ Dissemination