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Whole-cell patch-clamp was conducted in M-1 cells to record Na+ current before and after exposure to urine collected from; A) sham and CHF rats with or without amiloride, B) sham and CHF rats with or without aprotinin added, and C) control (Human) and CHF patients. n = 4/group * P < 0.05 vs. sham/control. # P < 0.05 vs. CHF.
