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Urine flow (A) and Na+ excretion (B) in response to benzamil injection in sham and CHF rats with or without pretreatment with aprotinin for 2 weeks. (C) Whole-cell patch-clamp was conducted in M-1 cells to record inward current before and after exposure to urine collected from CHF rats with or without aprotinin treatment. * P < 0.05 vs. sham. # P < 0.05 vs. CHF.
