Table 1.

Demographics and clinical information for patients with clinical stage I NSCLC that were or were not upstaged following surgical resection – Continuous variables are displayed as mean +/− standard deviation. Categorical variables are displayed as number (% total).

Patient Characteristics	Pathologic Stage I Patients n= 46,123		Upstaged patients n=9,530	p-Value
Age at diagnosis (years)	68.1 +/− 10.0		67.3 +/− 10.1	<0.001
Male Gender	21,794 (47%)		4,902 (51%)	<0.001
Caucasian	41,163 (89%)		8,440 (89%)	0.05
Academic Center	16,492 (36%)		3,597 (38%)	0.001
Annual Income >$35,000	29,233 (67%)		6,028 (67%)	0.61
Urban Area	29,824 (65%)		6,232 (65%)	0.18
Charlson/Deyo Score (CCI)	0	23,270 (50%)	4,943 (52%)	0.03
	1	16,507 (36%)	3,341 (35%)
	2	6,346 (14%)	1,246 (13%)
Tumor Size (mm)	28.6 +/− 21.1		37.7 +/− 23.7	<0.001
Latency >8 weeks	12,857 (28%)		2,801 (29%)	0.003
Clinical T Stage	1	30,404 (66%)	4,572 (48%)	<0.001
	2	15,719 (34%)	4,958 (52%)
Pathologic T Stage	1	26,804 (58%)	2,390 (25%)	<0.001
	2	19,319 (42%)	4,563 (48%)
	3	n/a	1,491 (16%)
	4	n/a	1,086 (11%)
Pathologic N Stage	0	46,123 (100%)	2,503 (26%)	<0.001
	1	n/a	4,736 (50%)
	2	n/a	2,272 (24%)
	3	n/a	19 (0.2%)
Pathologic M Stage	1	n/a	340 (4%)	<0.001
Complete Resection		45,018 (98%)	8,605 (90%)	<0.001
Mean Number of Lymph Nodes Examined		8.19 +/− 7.0	10.9 +/− 8.2	<0.001
Adjuvant Radiation		1,300 (3%)	1,582 (17%)	<0.001
Adjuvant Chemotherapy		4,440 (10%)	4,649 (51%)	<0.001
Surgery	Lobectomy	37,940 (82%)	7,801 (82%)	<0.001
	Pneumonectomy	1,072 (2%)	929 (10%)
	Wedge/segment	7,111 (15%)	800 (8%)