Table 2.

Multivariable logistic regression analysis identifying variables associated with upstaging in patients with clinical stage I NSCLC.

Patient and Treatment Variables	Odds ratio (OR) with 95% Confidence Interval (CI)	p-Value
Age	0.99 (0.99–0.99)	<0.001
Male gender	1.11 (1.05–1.17)	<0.001
Tumor Size (mm)	1.11 (1.10–1.13)	<0.001
Clinical T2 Status	1.52 (1.42–1.62)	<0.001
Latency > 8 weeks	1.10 (1.03–1.16)	0.002
Positive Tumor Margin	4.14 (3.70–4.63)	<0.001
Squamous Histology	0.82 (0.78–0.87)	<0.001
Number of Lymph Nodes Examined (n)
n=0 (2,565)	1.00	n/a
n=1–3 (9,523)	2.01 (1.62–2.50)	<0.001
n=4–6 (11,848)	2.99 (2.42–3.69)	<0.001
n=7–9 (9,406)	3.81 (3.09–4.71)	<0.001
n=10–12 (6,562)	4.19 (3.38–5.19)	<0.001
n=13–15 (4,126)	4.51 (3.62–5.62)	<0.001
n=16–18 (2,514)	5.90 (4.70–7.40)	<0.001
n>18 (4,528)	6.14 (4.94–7.62)	<0.001