Table 3.
Cox proportional hazards model identifying factors associated with long-term mortality in patients with clinical stage I NSCLC
| Patient and Treatment Variables | Hazard ratio (HR) with 95% Confidence Interval (CI) | p-Value |
|---|---|---|
| Age | 1.03 (1.03–1.03) | <0.001 |
| Male gender | 1.37 (1.33–1.42) | <0.001 |
| Caucasian Race | 1.08 (1.02–1.15) | 0.007 |
| Academic Facility | 0.96 (0.93–0.99) | 0.03 |
| Urban Location | 0.96 (0.92–0.99) | 0.02 |
| Income >$35,000 | 0.90 (0.87–0.93) | <0.001 |
| Charlson Score =1 | 1.14 (1.10–1.18) | <0.001 |
| Charlson Score =2 | 1.49 (1.42–1.56) | <0.001 |
| Tumor Size (mm) | 1.03 (1.02–1.03) | <0.001 |
| Clinical T2 Status | 1.24 (1.19–1.28) | <0.001 |
| Positive Tumor Margin | 1.49 (1.39–1.60) | <0.001 |
| Upstaged Tumor | 1.85 (1.78–1.92) | <0.001 |
| Number of Lymph Nodes Examined (n) – all patients | ||
| n=0 | 1.00 | n/a |
| n=1–3 | 0.80 (0.74–0.86) | <0.001 |
| n=4–6 | 0.69 (0.65–0.75) | <0.001 |
| n=7–9 | 0.67 (0.62–0.72) | <0.001 |
| n=10–12 | 0.64 (0.59–0.69) | <0.001 |
| n=13–15 | 0.65 (0.60–0.71) | <0.001 |
| n=16–18 | 0.62 (0.56–0.69) | <0.001 |
| n>18 | 0.66 (0.61–0.72) | <0.001 |
| Number of Lymph Nodes Examined – Non-upstaged only | ||
| n=0 | 1.00 | n/a |
| n=1–3 | 0.78 (0.72–0.84) | <0.001 |
| n=4–6 | 0.69 (0.64–0.74) | <0.001 |
| n=7–9 | 0.65 (0.60–0.71) | <0.001 |
| n=10–12 | 0.64 (0.58–0.69) | <0.001 |
| n=13–15 | 0.66 (0.60–0.73) | <0.001 |
| n=16–18 | 0.64 (0.57–0.72) | <0.001 |
| n>18 | 0.67 (0.61–0.74) | <0.001 |