Figure 5.
EVOO-enriched diet stimulated the ApoE-dependent clearance pathway of Aβ through the activation of PPARγ. (A) Representative blots and densitometry analysis of ABCA1 and ApoE showed significant up-regulation in their expressions in the brain tissue of TgSwDI mice after consumption of EVOO-enriched diet. (B) Representative blot and densitometry analysis show significant induction in the expression of PPARγ in both groups while expression of LXR was enhanced only in EVOO-6m group. Data is presented as mean±SEM of 4–6 mice in each group (ns, not significant; and * P<0.05).