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LARG is phosphorylated and dephosphorylated during mitosis, which regulates the GEF activity. Cdk1 phosphorylates LARG in early mitosis (G2/M) resulting in decreased GEF activity. LARG is then dephosphorylated, relieving the inhibition of GEF activity, as cells proceed past the anaphase transition towards mitotic exit. See text for further discussion.
