TABLE 2.
Association of Achieved SBP and Outcomes
| SBP < 124 mmHg (N=747) |
SBP ≥124 mmHg (N=2000) |
||
|---|---|---|---|
| Model | HR per SD* Higher SBP (95% CI) |
p-value for interaction |
|
| All Stroke | |||
| # of events | 45 | 130 | |
| Model 1† | 0.44 (0.21, 0.93) | 1.3 (1.1, 1.7) | 0.005 |
| Model 2† | 0.40 (0.19, 0.84) | 1.3 (0.97, 1.7) | 0.005 |
| Model 3† | 0.43 (0.17, 1.1) | 1.1 (0.76, 1.6) | 0.02 |
| Ischemic Stroke | |||
| # of events | 38 | 110 | |
| Model 1† | 0.43 (0.19, 0.99) | 1.4 (1.1, 1.7) | 0.01 |
| Model 2† | 0.38 (0.17, 0.87) | 1.3 (0.92, 1.7) | 0.01 |
| Model 3† | 0.41 (0.15, 1.1) | 1.0 (0.70, 1.6) | 0.03 |
| Major Vascular Events | |||
| # of events | 53 | 178 | |
| Model 1† | 0.45 (0.22, 0.90) | 1.4 (1.2, 1.7) | 0.001 |
| Model 2† | 0.41 (0.20, 0.84) | 1.4 (1.1, 1.8) | 0.0008 |
| Model 3† | 0.53 (0.22, 1.3) | 1.1 (0.84, 1.5) | 0.005 |
| Death | |||
| # of events | 38 | 119 | |
| Model 1† | 0.45 (0.20, 1.0) | 1.5 (1.2, 1.8) | 0.001 |
| Model 2† | 0.40 (0.17, 0.93) | 1.9 (1.5, 2.4) | <0.001 |
| Model 3† | 0.29 (0.10, 0.79) | 1.9 (1.4, 2.7) | <0.001 |
*
11.1 mmHg
†
Model 1 includes age, sex, ethnicity, region, smoking, alcohol use, BMI, baseline SBP, baseline DBP, history of hypertension, diabetes, heart disease, or prior stroke/TIA; Model 2 adds number of medications at baseline and number of medications at 1 year follow-up, and randomization group, Model 3 adds achieved DBP (linear and quadratic term)