Table II.
Studies investigating the association of ischemic or bleeding events and clopidogrel response with use of Multiplate Electrode Aggregometry (MEA)
| Study author/acronym | Method:agonist | N | Population | Follow-up | Outcome | OR/HR | Cut-off value | Prevalence of HPR/LPR (%) | AUC | PPV (%) | NPV (%) | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Thrombosis | |||||||||||||
| Sibbing et al. [46] | MEA:ADP | 1608 | Elective PCI | 1 month | ST | 9.40 | 468AU*min = 47 U | 20 | 0.78 | 70 | 84 | ||
| Sibbing et al. [64, 65] | MEA:ADP | 2533 | Elective PCI | 1 month | ST | 0.40 | 468AU*min = 47 U | 17 | |||||
| Eshtehardi et al. [66] | MEA:ADP | 219 | PCI | 1 month | MACE | 309AU*min = 31 U | 15 | ||||||
| Müller-Schunk et al. [194] | MEA:ADP | 50 | Neurointerventional stent | ST+TIA/stroke | 52 U | 28 | |||||||
| Siller-Matula et al. [195] | MEA:ADP | 403 | PCI | 1 year | MACE | 1.75 | 48 U | 19 | 0.60 | ||||
| PEGASUS-PCI [63] | MEA:ADP | 416 | PCI | 1 year | ST, MACE | 46 U | 38 | 0.78 | 7 | 100 | 70 | 67 | |
| Dineva et al. [67] | MEA:ADP | 603 | PCI | 1 month | ST | 24.3 | 46 U | 18 | 0.86 | 84 | 78 | ||
| Siller-Matula et al. [48] | MEA:ADP+PGE1 | 416 | PCI | 6 months | ST | 54 U | 14 | 0.92 | 5 | 100 | 86 | 100 | |
| PEGASUS-PCI [63] | MEA:ADP+PGE1 | 416 | PCI | 1 year | ST, MACE | 36.9 | 48 U | 19 | 0.90 | 13 | 100 | 90 | 83 |
| Bleeding | |||||||||||||
| Rahe-Meyer et al. [128] | MEA:ADP | 60 | Cardiac surgery | In hospital | Blood Transfusion | 13 U | 33 | 0.74 | 77 | 63 | |||
| Sibbing et al. [64, 65] | MEA:ADP | 2533 | PCI | In hospital | TIMI major bleeding | 3.50 | 188AU*min = 19 U | 38 | 0.61 | 2 | 99 | 62 | 62 |
| Ranucci et al. [129] | MEA: ADP | 87 | Thienopyridine treatment | In hospital | Postoperative bleeding | 31 U | 40 | 0.71 | 29 | 92 | 72 | 66 | |
| PEGASUS-PCI [63] | MEA:ADP+PG | 416 | PCI | 1 year | TIMI major bleeding | Ns | 20 U |
ADP – adenosine diphosphate, PGE1 – prostaglandin E1, AUC – area under the curve (of the receiver operating curve – c-index), PPV – positive predictive value, NPV – negative predictive value, HPR – high platelet reactivity (prevalence is given for studies investigating thrombotic events), LPR – low platelet reactivity (prevalence is given for studies investigating bleeding events), PCI – percutaneous coronary intervention, MACE – major adverse cardiac events, ST – stent thrombosis, TIA – transient ischemic attack, TIMI – thrombolysis in myocardial infraction, NS – not significant.