Skip to main content
. 2015 Dec 16;35(50):16362–16376. doi: 10.1523/JNEUROSCI.1392-15.2015

Figure 5.

Figure 5.

Dnmt3a knock-out from NAc in females promotes resilience to SCVS. a, Schematic of surgery, SCVS procedure, and behavioral testing. b, Validation of Dnmt3a knock-out by mRNA expression levels in NAc (n = 5–11 per condition). c, Dnmt3a knock-out from NAc blocks the decrease in grooming caused by SCVS in females (n = 8–11/sex/virus for behavioral testing). d, Dnmt3a knock-out from NAc blocks the increased latency to eat in the novelty suppressed feeding test in females. e, Dnmt3a knock-out from NAc blocks the decreased sucrose preference in females. f, Dnmt3a knock-out from NAc blocks the increase in passive coping in the FST in females. No effect of Dnmt3a knock-out was evident in males. g, There was no effect of excising Dnmt3a or sex on anxiety associated exploratory behavior in the EPM. h, There were no effects of Dnmt3a knock-out or sex on locomotor activity. *Significant interaction between sex and virus (two-way ANOVA followed by Bonferroni post hoc analysis).∧ indicates a main effect of virus.