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Types of interaction between dimeric naphthoquinone derivatives and doxorubicin in MDR mouse T-cell lymphoma cell line.
| Compounds | Ratio | ED50 | CI | Interaction |
|---|---|---|---|---|
| 1 | 1.724:25 1.724:25 0.862:50∗ |
1.85494 1,77987 1,66629 |
1.302 | Moderate antagonism |
| 2 | 6.897:25∗ 3.448:50 0.862:50 |
1.24794 1.65175 1.66558 |
1.175 | Slight antagonism |
| 3 | 6.897:50 3.448:50 3.448:100∗ |
2.36396 2.49152 1.80217 |
1.459 | Antagonism |
CI, combination index. ∗Best ratio.
