Table 1.

E3 ligases can promote or inhibit activation of T cells.

Promotes T cell activation and proliferation	Limits T cell activation	Ties T cell activation to co-stimulation	Induces T cell anergy
Nedd4	Itch	TRIM30	GRAIL
WWP2	Nedd4-2	TRAF6	Cbl-b
TRIM28	TRIM27	Cbl-b	Itch
Cul1	Peli1	Itch
Stub1	Cbl-b
TRAF6	(c-Cbl)
TRAF2