FIG. 1.

Effects of TSE (A), nicotine 0.2 mg/kg/day (B), and nicotine 2 mg/kg/day (C) on ChAT activity. Data represent means and standard errors, presented as the percent change from control values; complete original data are shown in Supplementary Table S2. Multivariate ANOVA for each treatment appears at the top of the panels. Lower-order tests for each sex were carried out only where there was a treatment × sex interaction (A, C). Effects on specific regions and ages are shown where justified by interactions with treatment; for females in panel A, there was an interaction of treatment with both age and region, so asterisks denote individual values that differ from control. Panel (D) shows the simple main treatment effects, collapsed across age and region.