FIG. 6.

Effects of TSE (A), nicotine 0.2 mg/kg/day (B), and nicotine 2 mg/kg/day (C) on 5HT₂ receptor binding. Data represent means and standard errors, presented as the percent change from control values; complete original data are shown in Supplementary Table S6. Multivariate ANOVA for each treatment appears at the top of the panels. Lower-order tests for each sex were carried out for each treatment because of a significant treatment × sex interaction. Effects on specific regions or ages were not carried out because of the absence of their interactions with treatment. Panel (D) shows the simple main treatment effects, collapsed across age and region.