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. 2015 Dec 16;8:75. doi: 10.3389/fnmol.2015.00075

Table 4.

rpS6 phosphorylation in genetic mouse models.

Model Brain area/cell-type S235/236 S240/244 References
KNOCKOUT
Akt3 Whole brain ↓ ↓ Easton et al., 2005
Tsc2+∕− Hippocampus ↑ ND Ehninger et al., 2008
Hdc Striatum ↑ = Rapanelli et al., 2014
Fmr1 Hippocampus/pyramidal cells ↑ ↑ Bhattacharya et al., 2012
S6K2 Hippocampus ↓ = Antion et al., 2008a
Mecp2 Cortex/principal cells ↓ ↓ Ricciardi et al., 2011
Cerebellum ↓ ↓ Ricciardi et al., 2011
Hippocampus ↓ = Ricciardi et al., 2011
miR-199a-2 Cortex/principal cells ↓ ND Tsujimura et al., 2015
Hippocampus/pyramidal cells ↓ ND Tsujimura et al., 2015
Cdkl5 Cortex/principal cells ↓ ↓ Amendola et al., 2014
DAT Nucleus accumbens ↑ ND Sutton and Caron, 2015
Lepob∕ob Hypothalamus (arcuate) ND ↑ Villanueva et al., 2009
Leprdb∕db Hypothalamus (arcuate) ND ↑ Villanueva et al., 2009
CONDITIONAL KNOCKOUT
Tsc1Syn1 Cortex/principal cells ND ↑ Meikle et al., 2007
Hippocampus ND ↑ Meikle et al., 2007
Tsc1GFAP Cortex ↑ ND Parker et al., 2011
Cortex ↑ (NS) ↑ (NS) Zeng et al., 2008, 2011
Hippocampus ↑ (NS) ↑ (NS) Zeng et al., 2008, 2011
Tsc1AAV−CreGFP Hippocampus/pyramidal cells ND ↑ Bateup et al., 2011
Tsc1MCH Hypothalamus ↑ ND Knight et al., 2012
Tsc1L7 Cerebellum/purkinje cells ↑ (NS) ↑ (NS) Tsai et al., 2012
Tsc1Emx1 Cortex/principal cells ↑ ND Magri et al., 2011
Tsc1CaMKII Cortex ↑ ND McMahon et al., 2012
Hippocampus ↑ ND McMahon et al., 2012
Tsc1Temporal# Cortex ND ↑ Feliciano et al., 2011
Tsc2GFAP1 Cortex ↑ (NS) ↑ (NS) Zeng et al., 2011
Hippocampus ↑ (NS) ↑ (NS) Zeng et al., 2011
Tsc2hGFAP Cortex/principal cells ND ↑ Way et al., 2009
Hippocampus/principal cells ND ↑ Way et al., 2009
Tsc2CaMKII Hippocampus/principal cells ND ↑ Rozas et al., 2015
Rheb1Nestin Hypothalamus ↓ ↓ Zou et al., 2011; Yang et al., 2014
Cortex ↓ ↓ Zou et al., 2011
Cerebellum ↓ ↓ Zou et al., 2011
Hippocampus ↓ ↓ Zou et al., 2011
RhebGFAP Hippocampus/granule cells ND ↑ Banerjee et al., 2011
PtenGFAP* Hippocampus/granule cells ↑ ↑ Kwon et al., 2003; Chalhoub et al., 2006; Lugo et al., 2013
Cerebellum ↑ ND Kwon et al., 2003
PtenGFAP*/S6K1 ko Hippocampus/granule cells ↑ ND Chalhoub et al., 2006
PtenNestin Hippocampus/granule cells ↑ ND Kwon et al., 2006; Zhou et al., 2009
Cortex ↑ ND Zhou et al., 2009
PtenDATCreERT2 Ventral midbrain/DA neurons ↑ ND Domanskyi et al., 2011
RictorNestin Whole brain = ND Thomanetz et al., 2013
Dicer1CaMKCreERT2 Hypothalamus/arcuate nucleus ↑ ND Vinnikov et al., 2014
TARGETED MUTATION
Ube3Atm1Alb∕J Cerebellum/purkinje cells ↑ ↑ Sun et al., 2015
Tsc2DRG Hippocampus ↑ = Chévere-Torres et al., 2012
Ts1Cje Hippocampus/principal cells ↑ ND Troca-Marín et al., 2011
N171-N82Q Striatum ↓ ND Ravikumar et al., 2004; Lee et al., 2015
Cortex ↓ ND Ravikumar et al., 2004
Cortex ↓ = Fox et al., 2010
3xTg-AD Whole brain ↑ ND Caccamo et al., 2015
VIRAL-MEDIATED GENE TRANSFER
DISC1-shRNA Hippocampus/granule cells ↑ ND Kim et al., 2009; Zhou et al., 2013
S6K1CA Prefrontal cortex ↑ ND Dwyer et al., 2015
S6K1DN Prefrontal cortex ↑ ND Dwyer et al., 2015
*

The Gfap-Cre mice used in these studies lead to Pten deletion in a subset of neuronal cells, including the majority of granule cells in the dentate gyrus and cerebellum.

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In utero electroporation to express Cre recombinase and remove Tsc1 in Tsc1floxed∕mutant heterozygous embryos at E16. NS, not specified; ND, not determined; DA, dopaminergic.