Table 4.
Associations between rs16969968 and outcomes stratified by smoking status
| Outcome category | Outcome | Current smokers | Never smokers | Ever smokers |
|---|---|---|---|---|
| Regression coefficient (95% CI) | ||||
| Physical capability | Grip strength | 0.008 (−0.044 to 0.061) | 0.016 (−0.030 to 0.062) | −0.015 (−0.037 to 0.008) |
| Chair rise speed | 0.003 (−0.123 to 0.130) | 0.000 (−0.078 to 0.079) | −0.002 (−0.048 to 0.044) | |
| Walk speed | 0.049 (−0.122 to 0.220) | 0.026 (−0.015 to 0.068) | 0.002 (−0.033 to 0.038) | |
| TUG speed | −0.043 (−0.154 to 0.067) | −0.015 (−0.083 to 0.054) | −0.024 (−0.077 to 0.029) | |
| Cognitive capability | Mill Hill | 0.062 (−0.058 to 0.182) | −0.031 (−0.096 to 0.034) | −0.042 (−0.214 to 0.129) |
| NART | 0.020 (−0.075 to 0.116) | −0.009 (−0.098 to 0.080) | −0.004 (−0.058 to 0.051) | |
| Gf | 0.048 (−0.011 to 0.108) | −0.035 (−0.074 to 0.004) | 0.016 (−0.015 to 0.047) | |
| AH4 | 0.024 (−0.069 to 0.118) | −0.040 (−0.102 to 0.021) | 0.013 (−0.038 to 0.064) | |
| Semantic fluency | 0.028 (−0.038 to 0.094) | −0.013 (−0.048 to 0.022) | 0.014 (−0.014 to 0.042) | |
| Phonemic fluency | −0.033 (−0.160 to 0.094) | −0.018 (−0.085 to 0.048) | −0.126 (−0.398 to 0.145) | |
| Search speed† | 0.024 (−0.045 to 0.093) | −0.060* (−0.116 to −0.003) | 0.005 (−0.028 to 0.038) | |
| Word recall | 0.045 (−0.009 to 0.099) | −0.018 (−0.058 to 0.023) | 0.015 (−0.014 to 0.044) | |
| OR (95% CI) | ||||
| Physical capability | Inability to balance on one leg for 5 s | 1.010 (0.732 to 1.394) | 1.052 (0.896 to 1.236) | 0.921 (0.817 to 1.038) |
| Cognitive capability decline | Mill Hill | 0.535 (0.063 to 4.559) | 0.943 (0.798 to 1.114) | 0.935 (0.802 to 1.089) |
| NART | 1.016 (0.678 to 1.522)‡ | 0.878 (0.559 to 1.379) | 1.085 (0.848 to 1.388) | |
| AH4 | 1.007 (0.786 to 1.289) | 1.127 (0.955 to 1.329) | 0.925 (0.807 to 1.060) | |
| Semantic fluency | 0.975 (0.748 to 1.271) | 1.243 (0.926 to 1.670) | 0.984 (0.891 to 1.086) | |
| Phonemic fluency | 1.003 (0.735 to 1.369)§ | 1.097 (0.807 to 1.492) | 1.163 (0.565 to 2.393) | |
| Word recall | 0.999 (0.832 to 1.201) | 1.024 (0.913 to 1.149) | 0.978 (0.890 to 1.074) | |
Models adjusted for age and sex.
*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.
†Natural log transformed.
‡Analysis in CAPS only.
§Analysis in WHII only.
AH4, Alice-Heim 4-I test; Gf, general fluid; NART, National Adult Reading Test; TUG, timed get up and go.