Table 1.
Reference values for coagulation tests in healthy full-term children.
| Day 1 | Day 3 | 1 Month–1 Year | 1–5 Years | 6–10 Years | 11–16 Years | Adults | |
|---|---|---|---|---|---|---|---|
| aPPT results (sec) | |||||||
| PTT-A | 38.7 (34.3–44.8) | 36.3 (29.5–42.2) | 39.3 (35.1–46.3) | 37.7 (33.6–43.8) | 37.3 (31.8–43.7) | 39.5 (33.9–46.1) | 33.2 (28.6–38.2) |
| CK Prest | NA | NA | 34.4 (31.1–36.6) | 32.3 (29.8–35.0) | 32.9 (30.8–34.8) | 34.1 (29.4–40.4) | 29.1 (25.7–31.5) |
| Actin FSL | NA | NA | 37.4 (33.4–41.4) | 36.7 (31.8–42.8) | 35.4 (30.1–40.4) | 38.1 (32.2–42.2) | 30.8 (27.1–34.3) |
| Platelin L | NA | NA | 36.5 (33.6–40.4) | 37.3 (32.5–43.8) | 35 (31.0–39.3) | 39.4 (32.6–49.2) | 31.3 (27.2–35.4) |
| Coagulation Tests | |||||||
| TCT (sec) | NA | NA | 17.1 (16.3–17.6) | 17.5 (16.5–18.2) | 17.1 (16.1–18.5) | 16.9 (16.2–17.6) | 16.6 (16.2–17.2) |
| PT (sec) | 15.6 (14.4–16.4) | 14.9 (13.5–16.4) | 13.1 (11.5–15.3) | 13.3 (12.1–14.5) | 13.4 (11.7–15.1) | 13.8 (12.7–16.1) | 13.0 (11.5–14.5) |
| INR | 1.26 (1.15–1.35) | 1.20 (1.05–1.35) | 1.00 (.86–1.22) | 1.03 (.92–1.14) | 1.04 (.87–1.20) | 1.08 (.97–1.30) | 1.00 (.80–1.20) |
| Fibrinogen (g/L) | 2.80 (1.92–3.74) | 3.30 (2.83–4.01) | 2.42 (.82–3.83) | 2.82 (1.62–4.01) | 3.04 (1.99–4.09) | 3.15 (2.12–4.33) | 3.1 (1.9–4.3) |
| Coagulation Factors (%) | |||||||
| II | 54 (41–69) | 62 (50–73) | 90 (62–103) | 89 (70–109) | 89 (67–110) | 90 (61–107) | 110 (78–138) |
| V | 81 (64–103) | 122 (92–154) | 113 (94–141) | 97 (67–127) | 99 (56–141) | 89 (67–141) | 118 (78–152) |
| VII | 70 (52–88) | 86 (67–107) | 128 (83–160) | 111 (72–150) | 113 (70–156) | 118 (69–200) | 129 (61–199) |
| VIII | 182 (105–329) | 159 (83–274) | 94 (54–145) | 110 (36–185) | 117 (52–182) | 120 (59–200) | 160 (52–290) |
| IX | 48 (35–56) | 72 (44–97) | 71 (43–121) | 85 (44–127) | 96 (48–145) | 111 (64–216) | 130 (59–254) |
| X | 55 (46–67) | 60 (46–75) | 95 (77–122) | 98 (72–125) | 97 (68–125) | 91 (53–122) | 124 (96–171) |
| XI | 30 (7–41) | 57 (24–79) | 89 (62–125) | 113 (65–162) | 113 (65–162) | 111 (65–139) | 112 (67–196) |
| XII | 58 (43–80) | 53 (14–80) | 79 (20–135) | 85 (36–135) | 81 (26–137) | 75 (14–117) | 115 (35–207) |
| Coagulation Inhibitors (%) | |||||||
| AT | 76 (58–90) | 74 (60–89) | 109 (72–134) | 116 (101–131) | 114 (95–134) | 111 (96–126) | 96 (66–124) |
| Protein C chromogenic | 36 (24–44) | 44 (28–54) | 71 (31–112) | 96 (65–127) | 100 (71–129) | 94 (66–118) | 104 (74–164) |
| Protein C clotting | 32 (24–40) | 33 (24–51) | 77 (28–124) | 94 (50–134) | 94 (64–125) | 88 (59–112) | 103 (54–166) |
| Protein S clotting | 36 (28–47) | 49 (33–67) | 102 (29–162) | 101 (67–136) | 109 (64–154) | 103 (65–140) | 75 (54–103) |
| D-Dimers | |||||||
| D-Dimers (ug/mL) | 1.47 (.41–2.47) | 1.34 (.58–2.74) | .22 (.11–.42) | .25 (.09–.53) | .26 (.10–.56) | .27 (.16–.39) | .18 (.05–.42) |
| TFPI ref values | |||||||
| TFPI free (ng/mL) | NA | NA | 7.13 (5.63–8.44) | 10.16 (5.06–9.05) | 6.69 (4.29–9.31) | 7.66 (5.15–8.74) | 10.70 (6.12–12.34) |
| TFPI total (ng/mL) | NA | NA | 77.49 (69.42–85.58) | 76.33 (61.27–89.80) | 73.99 (59.13–88.02) | 74.09 (61.63–87.36) | 87.49 (63.64–104.38) |
| ETP ref values | |||||||
| ETP (pM.min) | NA | NA | 4865 (2653–7162) | 4429 (2537–6084) | 5363 (2719–8938) | 7593 (3373–7516) | 8475 (7043–10,205) |
Adapted with permission from Monagle P, Barnes C, Ignjatovic V, et al. Developmental haemostasis. Impact for clinical haemostasis laboratories. Thromb Haemost. 2006;95:362–372.
aPTT, activated partial thromboplastin time; INR, international normalized ratio; PT, prothrombin time; AT, antithrombin; TFPI, tissue factor pathway inhibitor; ETP, endogenous thrombin potential; pM.min is a measurement unit. PTT-A (Dianostica Stago), CK Prest (Diagnostica Stago), FSL (Dade Behring), TCT (thrombin clotting time, Diagnostica Stago), Platelin L (Organon Teknika).