Table 2.
Association between occupation as a welder and methylation of CpG sites in F2RL3
| Variable | Unadjusted analysis | Adjusted analysis | Full model | |||
|---|---|---|---|---|---|---|
| β (95% CI) | p Value | β (95% CI) | p Value | β (95% CI) | p Value | |
| CpG_2 | 0.70 (−0.23 to 1.6) | 0.14 | 0.86 (−0.054 to 1.8) | 0.065 | 1.1 (0.094 to 2.0) | 0.031 |
| CpG_3 | 0.86 (0.26 to 1.5) | 0.0053 | 0.90 (0.30 to 1.5) | 0.0036 | 0.99 (0.37 to 1.6) | 0.0020 |
| CpG_4* | −0.15 (−1.6 to 1.4) | 0.85 | 0.24 (−1.2 to 1.6) | 0.74 | 0.83 (−0.62 to 2.3) | 0.26 |
| CpG_5 | −1.8 (−3.0 to −0.59) | 0.0036 | −1.6 (−2.8 to −0.43) | 0.0079 | −1.2 (−2.4 to 0.055) | 0.061 |
The β values presented for occupation as a welder versus control are derived from general linear models. Unadjusted analyses: F2RL3 methylation=intercept + β (occupation); adjusted analyses: F2RL3 methylation=intercept + β (occupation) + β1 (age) + β2 (previous smoking); and full model: F2RL3 methylation=intercept + β (occupation) + β1 (age) + β2 (previous smoking) + β3 (passive smoking) + β4 (education)+ β5 (current residence).
*The residuals for methylation levels for CpG_4 were not normally distributed when comparing welders and controls and log transformation did not improve the distribution.