Table 1. Echocardiography data of Ntg, MURC and MURC-Hsp70 Tg mice at ~12 months of age.
| Ntg | MURC | MURC-Hsp70 | |
|---|---|---|---|
| No. of animals | 3 | 4 | 5 |
| BW, g | 45.3±1.2 | 45.7±1.1 | 45.3±0.9 |
| HR, bpm | 532±67 | 475±25 | 474±48 |
| LVPW, mm | 0.98±0.04 | 0.81±0.04* | 0.76±0.02* |
| IVS, mm | 1.04±0.04 | 0.83±0.02** | 0.84±0.01** |
| LVEDD, mm | 4.05±0.19 | 4.09±0.10 | 5.30±0.26* † |
| LVESD, mm | 2.08±0.14 | 2.73±0.14 | 3.86±0.31* † |
| FS, % | 48±1 | 34±2* | 28±3** |
BW: body weight; HR: heart rate; LV: left ventricular; LVPW: LV posterior wall thickness; IVS: interventricular septum thickness; LVEDD: LV end-diastolic dimension; LVESD: LV end-systolic dimension; FS: fractional shortening. Data are shown as mean ± SEM. One way ANOVA followed by Fisher’s posthoc test.
*P<0.05 vs. Ntg
**P<0.0005 vs. Ntg
†P<0.05 vs. MURC Tg