Table 1.
Characteristics and results of eligible prognostic studies evaluating survival
| Study | Country | N (M/F) | Samples | Staning pattern | Cut off value | Positve/Negative | Univariate HR (95%CI)/P value | Multivariate HR (95%CI)/P value |
|---|---|---|---|---|---|---|---|---|
| Hou YC 2014 | China | 96 (63/33) | TMA | Cytoplasm | > 0% | 42/54 | 0.83/0.55-1.24/0.365 | 1.346 high/1.0 low/0.441-4.112/0.602 |
| Kim HS 2012 | Korea | 42 (28/14) | Whole tissue sections | Cytoplasm and Membrane | > 3 | 14/28 | 0.42/0.19-0.92/0.014 | 1.445/1.012-2.214/0.022 |
| Maeda S 2008 | Japan | 80 (52/28) | Whole tissue sections | Cytoplasm | > 0% | 48/32 | 0.52/0.32-0.85/0.0002 | 2.151/1.211-3.869/0.009 |
| Li XW 2011 | China | 35 (23/12) | Whole tissue sections | Membrane | ≥ 10% | 26/9 | 0.68/0.36-1.27/0.032 | NA |
| Cen G 2010 | China | 71 (50/21) | Whole tissue sections | Cytoplasm and Membrane | > 5% | 46/25 | 0.42/0.25-0.71/0.000 | NA |
| Mizukami T 2014 | Japan | 17 | Whole tissue sections | Membrane | > 1% | 5/12 | 3.59/1.01-12.72/0.0406 | NA |
| Chen K 2014 | China | 109 (71/38) | Whole tissue sections | Membrane | > 5% | 65/44 | 0.62/0.42-0.901/0.013 | 1.008/0.227-4.486/0.992 |
| Wang YC 2014 | China | 52 (31/21) | Whole tissue sections | Cytoplasm | > 3 | 39/13 | 0.35/0.19-0.65/0.001 | NA |
| Kure S 2012 | Japan | 105 (61/44) | Whole tissue sections | Membrane | > 0% | 45/60 | 0.75/0.51-1.11/0.1536 | NA |
| Chen L 2014 | China | 65 (44/21) | Whole tissue sections | Membrane | > 0% | 38/27 | 0.54/0.33-0.88/0.013 | NA |
| Immervoll H 2008 | Norway | 51 | TMA | Membrane | > 0% | 41/10 | 0.69/0.33-1.46/0.123 | NA |
Abbreviations: N (M/F): number (male/female); TMA: tissue microarrays; NA: unknown.