Table 2.

Main clinicopathological features and results of eligible studies

Study	Country	N (M/F)	Samples	P/N	Staning patterns	Cut off value	Lymph node metastasis		TNM stage		Differentiation
							CD133+	CD133-	CD133+	CD133-	CD133+	CD133-
							Negative/Positive	Negative/Positive	I+II/III+IV	I+II/III+IV	Well/poor	Well/poor
Hou YC 2014	China	96 (63/33)	TMA	42/54	Cytoplasm	> 0%	20/22	27/27	39/3	51/3	36/6	42/12
Kim HS 2012	Korea	42 (28/14)	Whole tissue sections	14/28	Cytoplasm and Membrane	> 3	NA	NA	NA	NA	10/4	21/7
Maeda S 2008	Japan	80 (52/28)	Whole tissue sections	48/32	Cytoplasm	> 0%	11/37	18/14	42/6	28/4	48/2	31/1
Li XW 2011	China	35 (23/12)	Whole tissue sections	26/9	Membrane	≥ 10%	2/18	7/8	9/17	8/1	21/5	8/1
Wang X 2009	China	58 (36/22)	Whole tissue sections	37/21	Cytoplasm	> 0%	14/23	17/4	18/19	16/5	22/15	17/4
Cen G 2010	China	71 (50/21)	Whole tissue sections	46/25	Cytoplasm and Membrane	> 5%	10/20	33/8	23/7	36/3	10/20	33/8
Mizukami T 2014	Japan	17	Whole tissue sections	5/12	Membrane	> 1%	3/2	8/4	3/1	12/1	4/1	7/5
Chen K 2014	China	109 (71/38)	Whole tissue sections	65/44	Membrane	> 5%	31/34	34/10	51/14	41/3	45/20	37/7
Wang YC 2014	China	52 (31/21)	Whole tissue sections	39/13	Cytoplasm	> 3	9/30	9/4	19/20	11/2	19/20	11/2
Shimizu K 2009	Japan	10 (4/6)	Whole tissue sections	10/0	Cytoplasm and Membrane	> 0%	NA	NA	5/5	0/0	8/2	0/0
Vizio B 2012	Italy	37 (15/22)	TMA	11/26	Membrane	> 1%	NA	NA	NA	NA	NA	NA
Tsukamoto N 2013	Japan	80	TMA	29/51	Cytoplasm	> 5%	12/17	14/37	0/29	1/50	28/1	42/9

Abbreviations: N (M/F): number (male/female); TMA: tissue microarrays; P/N: positive/negative; NA unknown.