Table 3.
Results of sensitivity analysis
| Categories | Studies (n) | Effect model | HR (95% CI) | P value |
|---|---|---|---|---|
| Samples | ||||
| Whole tissue sections | 9 | random | 0.54 (0.46-0.64) | < 0.00001 |
| Tissue microarray | 2 | random | 0.75 (0.53-1.07) | 0.12 |
| Staining patterns | ||||
| Membrane | 6 | random | 0.60 (0.48-0.74) | < 0.00001 |
| Cytoplasm | 3 | random | 0.60 (0.41-0.87) | 0.008 |
| Membrane and Cytoplasm | 2 | random | 0.42 (0.28-0.63) | < 0.00001 |
| Cut off scores | ||||
| > 0% | 5 | random | 0.66 (0.54-0.81) | < 0.00001 |
| > 1% | 1 | fixed | 3.59 (1.01-12.72) | 0.0406 |
| > 5% | 2 | random | 0.52 (0.36-0.74) | 0.0003 |
| > 10% | 1 | fixed | 0.68 (0.36-1.27) | 0.032 |
| Scores > 3 | 2 | random | 0.43 (0.26-0.70) | 0.0008 |
| Antibody | ||||
| Abcam | 2 | fixed | 0.67 (0.47-0.95) | 0.03 |
| Santa Cruz | 2 | fixed | 0.50 (0.34-0.73) | 0.0004 |
| Dako | 2 | fixed | 0.51 (0.30-0.85) | 0.01 |