Table 2.
Potential transcripts on chromosome 8q21-qter related to taxol-resistant in nasopharyngeal carcinoma
| ID1 | Gene title | Name | Fold change2 | Functions | ||
|---|---|---|---|---|---|---|
|
| ||||||
| A | B | C | ||||
| NM_002467 | v-myc myelocytomatosis viral oncogene homolog | MYC | 1.85 | 1.63 | 1.59 | Apoptosis, G1-S cell cycle,Wnt signaling |
| AW592604 | Topoisomerase I | TOP1MT | 1.81 | 1.92 | 1.54 | Inhibitor of apoptosis |
| NM_001146 | Angiopoietin 1 | ANGPT1 | 7.82 | 1.65 | 4.48 | Angiogenesis, inhibitor of apoptosis |
| AI742931 | Protein-phosphatase 1, subunit 16A | PPP1R16A | 1.95 | 1.53 | 1.63 | control of microtubule dynamics during mitosis |
| U79297 | Ankyrin repeat domain 46 | ANKRD46 | 1.73 | 1.48 | 4.71 | Protein interaction,cell cycle, cancer progression |
| AI380298 | Syndecan 2 | SDC2 | 2.35 | 1.97 | 1.71 | cell proliferation, migration |
| M36532 | Carbonic anhydrase II | CA2 | 4.57 | 1.58 | 3.78 | Carbon dioxide transport cell proliferation |
| NM_030895 | Zinc finger protein 696 | ZNF696 | 2.18 | 1.85 | 1.50 | Zinc ion binding, gene regulation |
| NM_017767 | Solute carrier family 39, member 4 | SLC39A4 | 1.81 | 4.35 | 1.86 | Zinc ion binding, gene regulation |
| D31765 | Processing of precursor 1 | POP1 | 4.18 | 1.51 | 1.67 | Ribonuclease MRP complex |
| N54448 | Heat responsive protein 12 | HRSP12 | 5.09 | 1.96 | 2.02 | Regulation translational termination |
| NM_023078 | Pyrroline-carboxylate reductase like | PYCRL | 2.85 | 2.79 | 4.40 | Proline biosynthetic process |
| AU150691 | Hypothetical protein | ? | 2.07 | 1.68 | 2.38 | Unknown |
| H78106 | Hypothetical protein | ? | 1.64 | 2.23 | 3.41 | Unknown |
| BF445343 | NudC domain 1 | NUDCD1 | 2.13 | 1.90 | 1.74 | Unknown |
1
an identification number in public gene database.
2
fold change of mRNA expression level expressed as taxol-resistant cells divided by parental cells.
A: CNE-1/Taxol divided by CNE-1; B: 5-8/F/Taxol divided by 5-8/F; C: HNE-2/Taxol divided by HNE-2.