Table 1.
Characteristics of the case-control studies included in the meta-analysis
| First Author | Year | Population | Genotyping method | Cases/Controls | SNP studied | Male Patients (%) | Male Controls (%) | Age of cases | Age of controls | Diagnosis method | Control source |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Barreiro et al. | 2006 | African (South African) | fluorescence polarization or TaqMan | 351/360 | -336A/G, -871A/G | 51.8 | 22 | 36.7±10.9 | 34.6±12.5 | Smear, culture | Healthy individuals |
| da Silva et al. | 2014 | Mixed (Brazilian) | Taq Man SNP genotyping assays | 95/164 | -336A/G, -871A/G, -139G/A | 63.2 | 34.8 | 24.8±17.6 | 21.6±2.4 | Baciloscopy or culture | Healthy unrelated individuals |
| Kobayashi et al. | 2011 | Asian (Indonesian) | Sequencing | 532/561 | -336A/G, -871A/G, -139G/A | 53.7 | DNR | 41.6±15.4 | 39.3±12.7 | Smear, radiologic, clinical symptoms | Healthy individuals |
| Naderi et al. | 2014 | Asian (Iran) | T-ARMS-PCR | 156/154 | -336A/G | 37.2 | 43.5 | 48.1±15.6 | 49.8±20.7 | Smear, culture, radiologic, clinical symptoms | Healthy individuals |
| Ogarkov et al. | 2012 | Caucasian (Russian) | Taq Man LNA technology | 101/177 | -336A/G | 76.3 | 71.8 | 42.3±12.1 | 41.9±9.2 | DNR | Healthy individuals |
| Olesen et al. | 2007 | African (Guinea-Bissau) | Taq Man SNP genotyping assays | 315/340 | -336A/G, -139G/A | 60.4 | 49.9 | 37.3 | 38.1 | Smear, culture, radiologic, clinical symptoms | Healthy unrelated donors |
| Selvaraj et al. | 2009 | Caucasian (Indian) | PCR-RFLP | 107/157 | -336A/G,-139G/A | 49.5 | 51 | 34.0±8.2 | 30.6±8.3 | Smear, culture, radiologic, clinical symptoms | Healthy individuals |
| Vannberg et al. (a) | 2008 | African (Gambian) | MALDI-TOF | 676/327 | -336A/G | DNR | DNR | DNR | DNR | Smear, culture and history | Healthy unrelated donors |
| Vannberg et al. (b) | 2008 | African (Guinean) | MALDI-TOF | 151/180 | -336A/G | DNR | DNR | DNR | DNR | Smear, culture and history | Healthy unrelated donors |
| Vannberg et al. (c) | 2008 | African (Guinea-Bissau) | MALDI-TOF | 162/141 | -336A/G | DNR | DNR | DNR | DNR | Smear, culture and history | Healthy unrelated donors |
| Vannberg et al. (d) | 2008 | African (Malawian) | MALDI-TOF | 244/295 | -336A/G | DNR | DNR | DNR | DNR | Smear, culture and history | Healthy unrelated donors |
| Zheng et al. | 2011 | Asian (China) | Sequencing | 237/244 | -336A/G, -871A/G | 65.4 | DNR | 44.6±17.7 | DNR | Culture, radiologic | Healthy individuals |
Abbreviations and definitions: T-ARMS-PCR, Tetra-amplification Refractory Mutation System -Polymerase Chain Reaction; PCR-RFLP, Restriction Fragment Length Polymorphism analysis of PCR amplified fragments; MALDI-TOF, Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry; DNR: data not reported.