Table 3.
Univariate analysis of clinicopathological factors associated with OS and PFS
| Factor | OS | PFS | ||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| HR | 95% CI | P | HR | 95% CI | P | |
| Sex (male/female) | 0.705 | 0.402-1.236 | 0.222 | 0.673 | 0.404-1.120 | 0.127 |
| Age (< 55/≥ 55 years) | 0.922 | 0.525-1.619 | 0.777 | 0.961 | 0.578-1.598 | 0.878 |
| Tumor site (colon/rectum) | 0.722 | 0.411-1.268 | 0.257 | 0.743 | 0.447-1.236 | 0.253 |
| Tumor size (< 5/≥ 5 cm) | 0.877 | 0.500-1.537 | 0.646 | 0.747 | 0.448-1.246 | 0.263 |
| Differentiation (poor/well+moderate) | 2.598 | 1.257-5.368 | 0.010 | 3.068 | 1.571-5.992 | 0.001 |
| Lymph nodal metastasis (Yes/No) | 5.797 | 2.699-12.448 | < 0.001 | 3.410 | 1.906-6.100 | < 0.001 |
| Distant metastasis (Yes/No) | 8.816 | 4.460-17.425 | < 0.001 | 6.851 | 3.527-13.308 | < 0.001 |
| TNM stage (III-IV/I-II) | 11.842 | 4.237-33.100 | < 0.001 | 4.550 | 2.396-8.641 | < 0.001 |
| CXCR7 (positive/negative) | 6.144 | 2.606-14.487 | < 0.001 | 3.722 | 1.966-7.046 | < 0.001 |