Table 3.
Univariate and multivariate analyses of prognostic factors in patients with breast cancer
| Variables | Univariable P-value (log-rank test) | Multivariable | |
|---|---|---|---|
|
| |||
| HR (95% CI) | P-value | ||
| Age (years) | |||
| <50 vs. ≥50 | 0.472 | ||
| Tumor size (cm) | |||
| D≤5 vs. D>5 | 0.053 | ||
| Histological grades | |||
| Well/Moderate vs. Poor | 0.037 | 1.12 (0.97-1.29) | 0.056 |
| TNM stagea | |||
| I-II vs. III-IV | 0.008 | 1.34 (1.18-1.51) | 0.011 |
| Lymph node metastasis | |||
| Negative vs. Positive | 0.003 | 1.41 (1.20-1.57) | 0.009 |
| No. of lymph node excised | |||
| N≤9 vs. N≥10 | 0.088 | ||
| ER | |||
| Negative vs. Positive | 0.147 | ||
| PR | |||
| Negative vs. Positive | 0.093 | ||
| HER-2 | |||
| Negative vs. Positive | 0.022 | 1.19 (0.96-1.34) | 0.053 |
| CA15-3 (U/ml) | |||
| <25 vs. ≥25 | 0.180 | ||
| CXCL12 mRNA expression | |||
| Low vs. High | 0.003 | 1.29 (1.15-1.44) | 0.019 |
| CXCR4 mRNA expression | |||
| Low vs. High | 0.001 | 1.36 (1.09-1.59) | 0.037 |
| CXCR7 mRNA expression | |||
| Low vs. High | <0.001 | 1.43 (1.27-1.62) | 0.002 |
a
TNM staging was classified according to the 7th edition of the AJCC cancer staging manual.
n, number of patients; D, diameter; N, number of lymph node excised; ER, estrogen receptor; PR, progesterone receptor; HER-2, human epidermal growth factor receptor-2.