Table 1.
Basic characteristics of selected variants in the Lhoba
| SNP ID | Genes | Allele | Categories | Lhoba | HWE | |||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| A | B | Family | Phase | MAF | AA-Count | AB-Count | BB-Count | |||
| rs10264272 | CYP3A5 | C | T | Cytochrome P450 superfamily | Phase I | 0 | 100 | 0 | 0 | / |
| rs1042713 | ADRB2 | G | A | Adrenergic receptors family | Others | 0.485 | 22 | 53 | 25 | 0.542 |
| rs1042714 | ADRB2 | G | C | Adrenergic receptors family | Others | 0.145 | 2 | 25 | 73 | 0.934 |
| rs1045642 | ABCB1 | A | G | ATP-binding cassette (ABC) transporters superfamiy | Others | 0.475 | 20 | 55 | 25 | 0.304 |
| rs1051266 | SLC19A1 | T | C | Solute carrier family | Others | 0.332 | 44 | 43 | 11 | 0.919 |
| rs1065776 | P2RY1 | T | C | G-protein coupled receptor family | Others | 0.01 | 0 | 2 | 98 | 0.920 |
| rs10929302 | UGT1A10 | G | A | UDP-glucuronosyltransferase family | Phase II | 0.071 | 86 | 12 | 1 | 0.440 |
| rs1128503 | ABCB1 | A | G | ATP-binding cassette (ABC) transporters superfamiy | Others | 0.28 | 50 | 44 | 6 | 0.361 |
| rs1142345 | TPMT | T | C | Methyltransferase superfamily | Phase II | 0.015 | 97 | 3 | 0 | 0.879 |
| rs1229984 | ADH1B | T | C | Alcohol dehydrogenase family | Phase I | 0.06 | 1 | 10 | 89 | 0.256 |
| rs12720441 | KCNH2 | G | A | Eag family | Others | 0 | 100 | 0 | 0 | / |
| rs12721634 | CYP3A4 | T | C | Cytochrome P450 superfamily | Phase I | 0 | 100 | 0 | 0 | / |
| rs1540339 | VDR | C | T | Nuclear receptor famiy | Others | 0.285 | 11 | 35 | 54 | 0.158 |
| rs1544410 | VDR | C | T | Nuclear receptor famiy | Others | 0.07 | 87 | 12 | 1 | 0.433 |
| rs1695 | GSTP1 | A | G | Glutathione S-transferase family | Phase II | 0.105 | 80 | 19 | 1 | 0.913 |
| rs17238540 | HMGCR | T | C | HMGCR | Phase I | 0 | 100 | 0 | 0 | / |
| rs17244841 | HMGCR | A | T | HMGCR | Phase I | 0 | 100 | 0 | 0 | / |
| rs1799853 | CYP2C9 | C | T | Cytochrome P450 superfamily | Phase I | 0 | 100 | 0 | 0 | / |
| rs1800460 | TPMT | C | G | Methyltransferase superfamily | Phase II | 0 | 0 | 0 | 100 | / |
| rs1800497 | DRD2 | G | A | G-protein coupled receptor family | Others | 0.24 | 57 | 38 | 5 | 0.677 |
| rs1800888 | ADRB2 | C | T | Adrenergic receptors family | Others | 0 | 100 | 0 | 0 | / |
| rs1801030 | SULT1A2 | C | T | Sulfotransferase family | Phase II | 0 | 100 | 0 | 0 | / |
| rs1801131 | MTHFR | T | G | Methylenetetrahydrofolate reductase family | Phase I | 0.301 | 47 | 43 | 8 | 0.673 |
| rs1801133 | MTHFR | G | A | Methylenetetrahydrofolate reductase family | Phase I | 0.227 | 58 | 37 | 4 | 0.524 |
| rs1801252 | ADRB1 | A | G | Adrenergic receptors family | Others | 0.135 | 75 | 23 | 2 | 0.879 |
| rs1801253 | ADRB1 | G | C | Adrenergic receptors family | Others | 0.211 | 6 | 29 | 62 | 0.310 |
| rs1801272 | CYP2A6 | A | T | Cytochrome P450 superfamily | Phase I | 0.015 | 0 | 3 | 97 | 0.879 |
| rs1805124 | SCN5A | T | C | Sodium channel gene family | Others | 0.115 | 77 | 23 | 0 | 0.194 |
| rs2032582 | ABCB1 | A | C | ATP-binding cassette (ABC) transporters superfamiy | Others | 0.459 | 23 | 47 | 16 | 0.352 |
| rs20417 | PTGS2 | C | G | PTGS2 | Phase I | 0.025 | 2 | 1 | 97 | 0.000 |
| rs2046934 | P2RY12 | G | A | G-protein coupled receptor family | Others | 0.21 | 4 | 34 | 62 | 0.805 |
| rs2066702 | ADH1B | G | A | Alcohol dehydrogenase family | Phase I | 0 | 100 | 0 | 0 | / |
| rs2066853 | AHR | G | A | AHR | Others | 0.235 | 57 | 39 | 4 | 0.397 |
| rs2228570 | VDR | T | C | Nuclear receptor famiy | Others | 0.43 | 14 | 58 | 28 | 0.067 |
| rs2239179 | VDR | T | C | Nuclear receptor famiy | Others | 0.18 | 69 | 26 | 5 | 0.233 |
| rs2239185 | VDR | G | A | Nuclear receptor famiy | Others | 0.371 | 41 | 40 | 16 | 0.251 |
| rs2740574 | CYP3A4 | A | T | Cytochrome P450 superfamily | Phase I | 0 | 100 | 0 | 0 | / |
| rs28371706 | CYP2D6 | C | G | Cytochrome P450 superfamily | Phase I | 0 | 100 | 0 | 0 | / |
| rs28371725 | CYP2D6 | G | A | Cytochrome P450 superfamily | Phase I | 0.02 | 96 | 4 | 0 | 0.838 |
| rs28399433 | CYP2A6 | G | T | Cytochrome P450 superfamily | Phase I | 0.145 | 1 | 27 | 72 | 0.374 |
| rs28399444 | CYP2A6 | A | T | Cytochrome P450 superfamily | Phase I | 0 | 100 | 0 | 0 | / |
| rs28399454 | CYP2A6 | C | T | Cytochrome P450 superfamily | Phase I | 0 | 100 | 0 | 0 | / |
| rs28399499 | CYP2B6 | T | C | Cytochrome P450 superfamily | Phase I | 0 | 100 | 0 | 0 | / |
| rs3211371 | CYP2B6 | C | T | Cytochrome P450 superfamily | Phase I | 0.5 | 0 | 100 | 0 | 0.000 |
| rs3745274 | CYP2B6 | G | T | Cytochrome P450 superfamily | Phase I | 0.153 | 70 | 26 | 2 | 0.818 |
| rs3782905 | VDR | G | C | Nuclear receptor famiy | Others | 0.1 | 1 | 18 | 81 | 1.000 |
| rs3807375 | KCNH2 | C | T | Eag family | Others | 0.275 | 6 | 43 | 51 | 0.433 |
| rs3814055 | NR1I2 | C | T | Nuclear receptor famiy | Others | 0.101 | 79 | 20 | 0 | 0.264 |
| rs3815459 | KCNH2 | C | T | Eag family | Others | 0.474 | 27 | 46 | 22 | 0.778 |
| rs3846662 | HMGCR | A | G | HMGCR | Phase I | 0.485 | 22 | 53 | 25 | 0.542 |
| rs3918290 | DPYD | C | T | DPYD | Phase I | 0 | 100 | 0 | 0 | / |
| rs4124874 | UGT1A10 | T | G | UDP-glucuronosyltransferase family | Phase II | 0.165 | 69 | 29 | 2 | 0.600 |
| rs4148323 | UGT1A10 | G | A | UDP-glucuronosyltransferase family | Phase II | 0.39 | 41 | 40 | 19 | 0.111 |
| rs4149056 | SLCO1B1 | T | C | Solute carrier family | Others | 0.045 | 91 | 9 | 0 | 0.637 |
| rs4244285 | CYP2C19 | G | A | Cytochrome P450 superfamily | Phase I | 0.28 | 51 | 42 | 7 | 0.677 |
| rs4986893 | CYP2C19 | G | A | Cytochrome P450 superfamily | Phase I | 0.02 | 96 | 4 | 0 | 0.838 |
| rs4986910 | CYP3A4 | A | G | Cytochrome P450 superfamily | Phase I | 0 | 99 | 0 | 0 | / |
| rs4986913 | CYP3A4 | G | A | Cytochrome P450 superfamily | Phase I | 0 | 100 | 0 | 0 | / |
| rs5030656 | CYP2D6 | AAG | / | Cytochrome P450 superfamily | Phase I | 0 | 100 | 0 | 0 | / |
| rs5219 | KCNJ11 | C | T | Inward-rectifier potassium channel family | Others | 0.434 | 28 | 55 | 15 | 0.158 |
| rs59421388 | CYP2D6 | C | G | Cytochrome P450 superfamily | Phase I | 0.01 | 98 | 2 | 0 | 0.920 |
| rs6025 | F5 | T | C | F5 | Others | 0 | 0 | 0 | 100 | / |
| rs61736512 | CYP2D6 | C | G | Cytochrome P450 superfamily | Phase I | 0 | 100 | 0 | 0 | / |
| rs6277 | DRD2 | G | A | G-protein coupled receptor family | Others | 0 | 100 | 0 | 0 | / |
| rs6791924 | SCN5A | G | A | Sodium channel gene family | Others | 0.005 | 99 | 1 | 0 | 0.960 |
| rs689466 | PTGS2 | T | C | PTGS2 | Phase I | 0.44 | 31 | 50 | 19 | 0.884 |
| rs698 | ADH1C | T | C | Alcohol dehydrogenase family | Phase I | 0.116 | 78 | 19 | 2 | 0.516 |
| rs701265 | P2RY1 | A | G | G-protein coupled receptor family | Others | 0.135 | 74 | 25 | 1 | 0.481 |
| rs7294 | VKORC1 | C | T | VKORC1 | Phase I | 0.055 | 90 | 9 | 1 | 0.180 |
| rs7626962 | SCN5A | G | T | Sodium channel gene family | Others | 0 | 100 | 0 | 0 | / |
| rs776746 | CYP3A5 | C | T | Cytochrome P450 superfamily | Phase I | 0.19 | 66 | 30 | 4 | 0.800 |
| rs7975232 | VDR | C | A | Nuclear receptor famiy | Others | 0.38 | 40 | 44 | 16 | 0.508 |
| rs975833 | ADH1A | G | C | Alcohol dehydrogenase family | Phase I | 0.42 | 32 | 45 | 17 | 0.865 |
| rs9934438 | VKORC1 | G | A | VKORC1 | Phase I | 0.055 | 1 | 9 | 90 | 0.180 |