Table 2.
Association between the IL-10 -1082A/G and -819T/C gene polymorphisms and the risk of ischemic stroke
| IL-10 gene | Patients | % | Controls | % | χ2-test | P value | P for HWE | OR (95% CI)1 | P value |
|---|---|---|---|---|---|---|---|---|---|
| -1082G/A | |||||||||
| Codominant | |||||||||
| GG | 95 | 36.54 | 123 | 47.31 | 1.0 (Ref.) | - | |||
| GA | 124 | 47.69 | 108 | 41.54 | 1.49 (1.01-2.19) | 0.04 | |||
| AA | 41 | 15.77 | 29 | 11.15 | 6.76 | 0.03 | 0.47 | 1.83 (1.02-3.29) | 0.03 |
| Dominant | |||||||||
| GG | 95 | 36.54 | 123 | 47.31 | 1.0 (Ref.) | - | |||
| GA + AA | 165 | 63.46 | 137 | 52.69 | 6.19 | 0.01 | 1.56 (1.08-2.25) | 0.01 | |
| Recessive | |||||||||
| GG+GA | 219 | 84.23 | 231 | 88.85 | 1.0 (Ref.) | - | |||
| AA | 41 | 15.77 | 29 | 11.15 | 2.38 | 0.12 | 1.49 (0.87-2.58) | 0.12 | |
| -819T/C | |||||||||
| Codominant | |||||||||
| TT | 104 | 40.00 | 116 | 44.62 | 1.0 (Ref.) | - | |||
| TC | 113 | 43.46 | 111 | 42.69 | 1.14 (0.77-1.68) | 0.5 | |||
| CC | 43 | 16.54 | 33 | 12.69 | 1.99 | 0.37 | 0.42 | 1.45 (0.83-2.55) | 0.16 |
| Dominant | |||||||||
| TT | 104 | 40.00 | 116 | 44.62 | 1.0 (Ref.) | - | |||
| TC+CC | 156 | 60.00 | 144 | 55.38 | 1.13 | 0.28 | 1.21 (0.84-1.74) | 0.29 | |
| Recessive | |||||||||
| TT+TC | 217 | 83.46 | 227 | 87.31 | 1.0 (Ref.) | - | |||
| CC | 43 | 16.54 | 33 | 12.69 | 1.54 | 0.21 | 1.36 (0.81-2.30) | 0.21 | |
1
Adjusted for sex, age, BMI, tobacco smoking, TC, LDL-c, HDL-c and TG.
HWE, Hardy-Weinberg equilibrium; OR, Odd’s ratio; CI, confidence interval.