Table 1.
Clinicopathological characteristics of patient samples and expression of CISD2 in liver cancer and correlation between CISD2 expression and clinicopathological characteristics of hepatic cancer patients (n=196)
| Characteristics | Total (n= 196) | CISD2 | Chi-square test | Fisher’s exact test | ||
|---|---|---|---|---|---|---|
|
| ||||||
| No or Low expression | High expression | |||||
|
| ||||||
| 87 (44.4%) | 109 (55.6%) | P-value | P-value | |||
| Gender | Male | 156 | 68 (43.6) | 88 (56.4) | 0.087 | 0.077 |
| Female | 40 | 19 (47.5) | 21 (52.5) | |||
| Age (years) | <60 | 155 | 71 (45.8) | 84 (54.2) | 0.121 | 0.098 |
| ≥60 | 41 | 16 (39.0) | 25 (61.0) | |||
| HBsAg | Negative | 18 | 16 (88.9) | 2 (11.1) | 0.002 | 0.001 |
| Positive | 178 | 71 (39.9) | 107 (60.1) | |||
| AFP | <200 ng/ml | 94 | 45 (47.9) | 49 (52.1) | 0.084 | 0.079 |
| ≥200 ng/ml | 102 | 42 (41.2) | 60 (58.8) | |||
| Edmonson grade | I–II | 135 | 58 (43.0) | 77 (57.0) | 0.965 | 0.929 |
| III–IV | 61 | 29 (47.5) | 32 (52.5) | |||
| Tumor size | <5 cm | 50 | 41 (82.0) | 9 (18.0) | 0.001 | 0.000 |
| ≥5 cm | 146 | 46 (31.5) | 100 (68.5) | |||
| Number of tumors | Single | 111 | 78 (70.3) | 33 (29.7) | 0.003 | 0.003 |
| Multiple | 85 | 9 (10.6) | 76 (89.4) | |||
| Liver cirrhosis | No | 72 | 33 (45.8) | 39 (54.2) | 0.173 | 0.135 |
| Yes | 124 | 54 (43.5) | 70 (56.5) | |||
| Tumor encapsulation | No | 91 | 43 (47.3) | 48 (52.7) | 0.401 | 0.364 |
| Yes | 105 | 44 (41.9) | 61 (58.1) | |||
| Surgical margin | <1 cm | 82 | 65 (79.3) | 17 (20.7) | 0.006 | 0.003 |
| ≥1 cm | 114 | 22 (19.3) | 92 (80.7) | |||
| Vascular invasion | No | 138 | 63 (45.7) | 75 (54.3) | 0.288 | 0.226 |
| Yes | 58 | 24 (41.4) | 34 (58.6) | |||
| One year Recurrence | No | 148 | 79 (53.4) | 69 (46.6) | 0.009 | 0.007 |
| Yes | 48 | 8 (16.7) | 40 (83.3) | |||
| Five year Recurrence | No | 59 | 36 (61.0) | 23 (39.0) | 0.000 | 0.000 |
| Yes | 137 | 51 (37.2) | 86 (62.8) | |||