. 2015 Oct 1;8(10):13725–13738.

Table 2.

Univariate and multivariate analyses of various prognostic parameters in patients with hepatic cancer Cox-regression analysis

5 year survival		Low expression		46.2% (39.1%~49.9%)
5 year survival		High expression		23.5% (19.7%~28.5%)

	No. patients	Univariate analysis		Multivariate analysis

		P	Regression coefficient (SE)	P	Relative risk	95% confidence interval
CISD2
Low expression	87	0.029	0.248 (0.243)	0.025	1.630	1.050-2.876
High expression	109	0.029	0.248 (0.243)	0.025	1.630	1.050-2.876
Tumor size
<5 cm	50	0.003	0.112 (0.075)	0.016	1.207	1.031-1.419
≥5 cm	146	0.003	0.112 (0.075)	0.016	1.207	1.031-1.419
Surgical margin
<1 cm	82	0.015	0.256 (0.241)	0.019	1.669	1.047-2.587
≥1 cm	114	0.015	0.256 (0.241)	0.019	1.669	1.047-2.587
One year Recurrence
No	148	0.007	0.237 (0.211)	0.008	3.264	1.543-6.430
Yes	48	0.007	0.237 (0.211)	0.008	3.264	1.543-6.430

CISD2 protein expression level in hepatic cancer significantly correlated with patient survival time (P<0.001); the correlation coefficient was -0.252 (-0.251), indicating that higher levels of CISD2 expression correlated with shorter survival time.