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. 2015 Dec 16;5:17336. doi: 10.1038/srep17336

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(A) Kyse30 cells transfected with either IGFBP-3 shRNA or an empty vector as a control were treated with or without IR (4 Gy) respectively and were lysed and subjected to an antibody microarray. (B,C) Portions of the array illustrate differential expression of cyclin E1 and cyclin-dependent kinase (CDK2) and phosphorylation of Smad2/3, Smad3, and retinoblastoma protein (Rb) in control cells, IGFBP-3-silenced Kyse30 cells, control cells after IR treatment and IGFBP-3-silenced Kyse30 cells after IR treatment .The fold change in cell cycle related proteins was measured. Each panel contains six replicates of a specific antibody–protein reaction. ^*Compared with control group (P < 0.05). (D) The expression and phosphorylation of key cell cycle proteins were demonstrated by western blot analysis.