Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Dec 16;5:18035. doi: 10.1038/srep18035

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(A) Structural alignment of native rSTING and rSTING-cGAMP. The native rSTING (grey) adopts an open conformation compared with the rSTING-cGAMP. The extended loop is shown in light-blue. Each chain of the rSTING-cGAMP is highlighted in a red or yellow color. (B) A close-up view of the rSTING-cGAMP interactions. (C) Luciferase analysis of the extended loop mutants. HEK293T cells were transfected with indicated rSTING mutations and IFN β-Luc reporter plasmids. A luciferase assay was performed after stimulation with 2′3′-cGAMP or 3′3′-cGAMP. (D) The cGAMP binding affinity as measured by ITC.