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. 2015 Dec 16;5:18300. doi: 10.1038/srep18300

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(A) MMP-3, MMP-9 and MMP-12 fold gene expression. MMP-12 down-regulated in the liver of Angiotensin-II treated group; (B) PPAR-α, PPAR-β and PPAR-γ down-regulated in Angiotensin-II- and both α-tocopherol- and β-carotene-treated animals; (C) PAI-1 up-regulated, and both tPA and uPA down-regulated in the Angiotensin-II-treated mice. α-tocopherol- and β-carotene-treated animals controlled PAI-1 expression and improved the levels of both tPA and uPA mRNA. (D) ICAM-1 and VCAM-1 down-regulated in the Angiotensin-II-treated group and up-regulated in both α-tocopherol- and β-carotene-treated Apoe^−/− mice.