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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Curr Opin Insect Sci. 2015 Oct 1;11:47–55. doi: 10.1016/j.cois.2015.09.003

Figure 4. Conservation of a protease cascade module.

Figure 4

In pathways in which clip domain substrates have been determined experimentally, a conserved pattern is evident. A non-CLIP modular serine protease activates a penultimate CLIP protease from clade C with a type 1 clip domain, which activates a terminal CLIP protease from clade B with a type 2 clip domain, which then activates an effector protein.