Fig. 5.

Sequential administration of low dose Ad-OSM and NDV-OSM is safe and inhibits progression of PDA tumors in hamsters. a Schematic representation of the experimental setting. Tumor-bearing hamsters were divided into 4 groups that received the following treatments: local administration of Ad-OSM at days 0 and 3, followed by two administrations of NDV-OSM at days 10 and 13 (Ad/NDV-OSM group, n = 12); the same viruses in the reverse order (NDV/Ad-OSM group, n = 12); Ad-GFP followed by NDV-GFP (Ad/NDV-GFP group, n = 5); or local injections of saline solution at days 0, 3, 10 and 13 (Control group, n = 19). All viral doses were 1 × 10⁸ iu/hamster. b Individual tumor volumes and group averages determined by necropsy one month after initiation of treatments. * p < 0.05