Table 2.
The variables related to a skewed TCR Vβ repertoire
| Non-skewed TCR Vβ | Skewed TCR Vβ | Odds ratio | P value | |
|---|---|---|---|---|
| Age (years, median) | 41 | 65 | 3.1a | < 0.05 |
| % of CMV seropositivity | 30.7 | 74.5 | 13.8b | < 0.05 |
| % of ESRD patients | 28.6 | 70.0 | 10.2c | < 0.05 |
| % of patients on renal replacement therapy | 35.8 | 48.4 | NS | |
| Underlying kidney disease (number) | ||||
| Nephrosclerosis/atherosclerosis/hypertensive nephropathy | 1 | 7 | NS | |
| Primary glomerulopathy | 0 | 3 | NS | |
| Diabetic nephropathy | 2 | 7 | NS | |
| Reflux nephropathy | 4 | 4 | NS | |
| Polycystic kidney disease | 2 | 7 | NS | |
| Other | 5 | 2 | ||
| Unknown | 0 | 1 |
Abbreviations: TCR T cell receptor, NS not significant
ameans the odds of a skewed TCR Vβ repertoire in elderly population is 3.1 times higher than in the young population
bmeans the odds of a skewed TCR Vβ repertoire in CMV- IgG seropositive population is 13.8 times higher than in the CMV- IgG seronegative population
Cmeans the odds of a skewed TCR Vβ repertoire in patients is 10.2 times higher than in the healthy individuals