Table 4.

In vivo antiplasmodial efficacy of compounds 1 in C57BL/6 mice blood infected with P. berghei

Test group	Average % parasitemia			% reduction of parasitemia
	Day 4	Day 6	Day 9	Day 9
Oral (20 mg/kg/day)	5.3 ± 3.9	22.7 ± 10	24.2 ± 5.6	3.7 ± 5.6
Oral (40 mg/kg/day)	5.9 ± 2	10.7 ± 5	48.6 ± 12	−93.8 ± 49.3
IV (4 mg/kg/day)	0.4 ± 0.4	1.8 ± 1.4	8.1 ± 5	61.9 ± 26
IV (8 mg/kg/day)	0	0.9 ± 0.9	5.1 ± 1.7	82.9 ± 2.5
Oral CQ (10 mg/kg/day)	0	0	2 ± 1.6	92.0 ± 0.4
Placebo	2.5 ± 2.4	7.3 ± 2.4	25.1 ± 0.4	–

Data represent mean ± standard data points obtained from five mice