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. Author manuscript; available in PMC: 2016 Oct 27.
Published in final edited form as: Semin Cell Dev Biol. 2015 Oct 27;45:24–31. doi: 10.1016/j.semcdb.2015.10.031

Fig. 2. Intracellular Ca2+ signaling pathways.

Fig. 2

ER Ca2+ depletion induces cytosolic entry of Ca2+ through the store-operated Ca2+ influx pathway, which is formed by the ER-localization stromal-interacting molecule 1 (STIM1) and the plasma membrane-localized Orai channels. Ca2+-mediated exchange between ER and mitochondria is dependent on the IP3R and the mitochondria Ca2+ uniporter (MCU). Ca2+ released through lysosomal TRPML1–3 channels and NAADP receptors may activate ER IP3R and RyRs to release more Ca2+.