Figure 5.
Model of transepithelial K+ secretion mediated in distal (upper) segments of Malpighian tubules of the yellow fever mosquito (Aedes aegypti) challenged to secrete K+ at high rates.9,15 Reabsorptive transport is generally attributed to proximal (lower) segments of insect Malpighian tubules that enter the gut.17,70,71 AE, Cl/HCO3 anion exchanger72; Na/K ATPase, ouabain-sensitive Na/K pump9; Kir1, AeKir1 channel15; gj, gap junction48; Kir2B, AeKir2B channel15; NKCC, Na/K/Cl cotransporter49,50; PP(sj), septate junctional paracellular pathway permeable to Cl39, 41; Cl(am), apical membrane Cl− channel of stellate cell73; NHA1, NHA2, Na/proton antiporters74; KCC, K/Cl cotransporter75; V-ATPase, electrogenic proton pump.34,76,77