Figure 14.

The effect of VU625 on mosquito Kir channels expressed in T-REx-HEK293 cells (A) and Xenopus oocytes (B). A. Strong inward rectification of K⁺ current (control) in T-REx-HEK293 cells expressing AeKir1. The inward current is markedly reduced by VU625 (0.9 µM), similar to the channel block by barium (Ba²⁺, 2 mM). B. Dose-response curves of currents mediated by AeKir1 and AeKir2B expressed in Xenopus oocytes and inhibited by VU625. Adapted from Raphemot et al.⁵¹