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. Author manuscript; available in PMC: 2015 Dec 16.
Published in final edited form as: Cell Rep. 2015 Nov 19;13(9):1747–1756. doi: 10.1016/j.celrep.2015.10.064

Figure 5. Narp is required for BDNF-dependent synaptic function.

Figure 5

(A) Representative mEPSC traces from untreated and BDNF-treated wild-type and Narp−/− cultures. Average mEPSC frequency (B) and amplitude (C) in untreated and BDNF-treated wild-type and Narp−/− cultures. (D) Representative PPR traces from untreated and BDNF-treated wild-type and Narp−/− hippocampal slices. (E) Average PPR for untreated and BDNF-treated wild-type and Narp−/− slices. (F) Mossy fiber LTP in untreated (n=8) and BDNF-treated (n=6) wild-type slices. Upper panel shows representative fEPSP traces before (grey trace) and after (black trace) HFS. (G) Mossy fiber LTP is impaired in Narp−/− group (n=6) and is unaffected by BDNF (n=5). Upper panel shows representative fEPSPs traces before (grey trace) and after (black trace) HFS. (H) Mossy fiber LTP and its enhancement by BDNF are impaired in the presence of U0126. Left panels shows representative fEPSP traces fEPSPs before (grey trace) and after (black trace) HFS. Data is reported as mean ± SEM.