Table 1.
Effects of GABAB receptor agonist baclofen, on the extracellular level of DA in PFC and in STR in the absence or presence of the GABAB antagonist CGP52432.
| Treatment | Prefrontal cortex | Striatum |
|---|---|---|
| Dopamine (% of baseline) | ||
| Control | 94 ± 3 (n = 6) | 71 ± 10 (n = 7) |
| Baclofen (50 µM) | 53 ± 6* (n = 6) | 67 ± 13 (n = 7) |
| CGP52432 (50 µM) | 113 ± 17# (n = 9) | 84 ± 9 (n = 8) |
| Baclofen + CGP | 155 ± 37 (n = 6) | 98 ± 20 (n = 6) |
Data are expressed as a percent of baseline values and showing the mean value of the (150–210 min) time period after baclofen and/or CGP52432 administration (*p = 0.00, #p = 0.16 relative to control).