*Each hazard ratio was computed using a restricted cubic spline model with the median change in CAC/year value of 0.26 as the reference and was adjusted for age, sex, race/ethnicity, education, income, baseline CAC, systolic blood pressure, body mass index, diabetes, smoking, total cholesterol, high-density lipoprotein cholesterol, antihypertensive medications, lipid-lowering therapies, aspirin, and left ventricular hypertrophy. Dotted-lines represent the 95% confidence interval.
CAC=coronary artery calcium.